There are three methods of dissolving hydroxypropyl methylcellulose, the user can choose the most convenient method according to the usage:
1 . Hot water method: Add 1/3 or 2/3 of the required amount of water into the container and heat it above 80°C, because hydroxypropyl methylcellulose HPMC does not dissolve in hot water. Thus the initial HPMC can be uniformly dispersed in hot water; then add the remaining amount of cold water or ice water to the hot water slurry, and cool the mixture after stirring.
2 . Powder mixing method: hydroxypropyl methylcellulose HPMC powder particles and an equal or greater amount of other powdery ingredients are fully dispersed by dry mixing, and then dissolved in water, then HPMC can be dissolved at this time without agglomeration.
3. Organic solvent wetting method: HPMC is pre-dispersed or wetted with organic solvents such as ethanol, ethylene glycol or oil, and then dissolved in water. Then HPMC can also be dissolved smoothly at this time.
Note: The surface-treated HPMC can be wetted with cold water first, then add ammonia water or alkaline water to adjust the pH to 8-10 to form a viscosity.